Researchers found that the Zika virus appears to create disorganization in the cellular layers of the placenta that keep toxins, bacteria and viruses from crossing, potentially allowing the virus to penetrate the fetus.
Promoting Zika-free communities worldwide
The mission of The Zika Foundation is to advance and rapidly deploy low-cost and sustainable interventions that halt the spread of Zika worldwide. The Zika Foundation solicits donations, funds in-country operations and manages educational activities and technology solutions for Zika prevention, mosquito control and medical interventions.
The spread of Zika
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The first step is to avoid mosquitos.
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The first vaccine to be approved for clinical trials by the U.S. is now undergoing human trials in the U.S., Canada and Puerto Rico. The vaccine has the potential to also protect the male reproductive organ, preserving fertility and restricting testicular damage.
Research shows that the Asian lineage Zika virus halted the proliferation of brain stem cells and hindered their ability to develop into brain nerve cells. The Zika infection was mainly found in glial cells, which provide support and insulation for the brain.
The medians and 95th percentiles for the time until the loss of detectable Zika virus RNA detection were 14 days and 54 days, respectively, whereas 90% of patients infected with dengue viruses clear RNA within 10 days after the onset of symptoms.
The FDA authorized Abbott’s molecular test to detect Zika virus in whole blood, which may detect the virus for a longer period (up to 2 months) and provide results within 5 to 7 hours. Plus, the test can distinguish Zika from other viruses.
The Zika virus vaccines market is estimated to generate $14,500M in 2017 and to reach $18,697M by 2022, growing at a CAGR of 5.2%. About 1.6 million individuals are infected with Zika virus, and the number is exponentially increasing.
Zika is able to cross the placental barrier and infect cells that line blood vessel walls by latching onto the protein on the cells’ surface. Researchers showed that the antibodies that bind to the AXL protein prevented Zika from entering cells.
Spillback of Zika virus into monkeys in South America has already started, potentially making it nearly impossible to get rid of the Zika virus.
Babies diagnosed with CZS continue to struggle in NE Brazil. As a result, many families held off pregnancy. The birthrate in Pernambuco, which includes Recife, fell 7% last year as 70% of Recife’s inhabitants contracted Zika in 2015 and 2016. The birthrate dropped 45% at private clinics.
Since 2015, 48 countries and territories in the Americas have confirmed Zika transmission through mosquitoes. Community education and participation of eliminating mosquito vectors and breeding sites are crucial tools in the long-term fight against Zika.